DirectorandactorMarkWebberexploresfamilydynamicsusinghisrealfamilyasthecastandreal-lifesituationsforthestorytocreateafilmthatauthenticallyblursthelinebetweennarrativeanddocumentary.FleshandBloodtellsthestoryofMark,amanreturninghomefromprisontolivewithhismotherandteenagebrotherintheinnercityofPhiladelphia.Attemptstorebuildhislifebecomefrustratedbystruggleswithsobriety,astrainedrelationshipwithhisactivistmother,theneglectofateenagebrotherwithAspergersandarehashedcycleofabandonmentbyaddictfathers.Adysfunctionalfamilytreesoonemergeswhoseeverybranchisnotonlybrokenbutlikelyunrepairable.